Toll-Like Receptors in Acute Kidney Injury

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy limited. Moreover, survivors show adverse long-term outcomes, including risk of developing recurrent AKI bouts, cardiovascular events, chronic disease. However, there are no specific treatments to decrease the consequences AKI. Epidemiological preclinical studies pathological role inflammation AKI, not only at acute phase but also progression Toll-like receptors (TLRs) key regulators inflammatory response have been many cellular processes activated during For that reason, a number anti-inflammatory agents targeting TLRs analyzed damage In this review, we updated recent knowledge about TLRs, TLR4, initiation development as well novel compounds these molecules diminish condition.